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Douglas Landsittel, PhD

  • Professor of Biomedical Informatics, Biostatistics, Medicine, and Clinical and Translational Science
  • Director of Biostatistics, Starzl Transplant Institute
  • Program Director, Expanding National Capacity in PCOR through Training
  • Core Faculty, Comparative Effectiveness Research Center, Department of Biomedical Informatics

Education & Training

  • BS, Applied Mathematics, University of Pittsburgh, 1992
  • PhD, Biostatistics, University of Pittsburgh, Graduate School of Public Health, 1997

Representative Publications

2020 Publications:

  • Salim, T.I., Nestlerode, L.C., Lucatorto, E.L., Wasserman, T.L., Din, H.A., Landsittel, D.P., Tevar, A.D., Johnson, J.T., Duarte-Rojo, A. and Dunn, M.A. 2020. Frailty as Tested by Gait Speed Is a Risk Factor for Liver Transplant Respiratory Complications. The American Journal of Gastroenterology. 2020 Jun 1;115(6):859-66.
  • Bae KT, Shi T, Tao C, Yu ASL, Torres VE, Perrone RD, Chapman AB, Brosnahan G, Steinman TI, Braun WE, Srivastava A, Irazabal MV, Abebe KZ, Harris PC, Landsittel DP, and the HALT PKD Consortium. Expanded Imaging Classification of Autosomal Dominant Polycystic Kidney Disease. Journal of the American Society of Nephrology. 2020 Jul 1;31(7):1640-51.
  • Lavu S, Vaughan LE, Senum SR, Kline TL, Chapman AB, Perrone RD, Mrug M, Braun WE, Steinman TI, Rahbari-Oskoui FF, Brosnahan GM, Bae KT, Landsittel D, Chebib FT, Yu ASL, Torres VE, Harris PE. 2020. The value of genotypic and imaging information to predict functional and structural outcomes in ADPKD. JCI Insight. 2020 Aug 6;5(15):e138724.
  • Landsittel D, Srivastava A, Kropf K. Methods for Causal Inference and Associated Educational Resources. Quality Management in Health Care. 2020 29(4):260–269
  • Wang LF, Li Y, Landsittel DP, Reis SE, Levesque MC, Jones DM, Gartland R, Avolio J, Shoushtari A, Qi Z, Dezfulian C, Moreland LW, Liang KP. Identifying Vulnerable Plaque in Rheumatoid Arthritis Using Novel Microbubble Contrast-Enhanced Carotid Ultrasonography and Serum Biomarkers. In Press (accepted April 3, 2020). Journal of Diagnostic Medical Sonography.
  • Louis K, Macedo C, Bailly E Ramaswami B Marrari M, Shi T, Landsittel D, Chandran U, Fadakar P, Yamada M, Chalasani G, Randhawa P, Zeevi A, Lefaucheur C, Metes D. Activated circulating memory TFH cells with self-renewal potential underlie the kidney allograft antibody-mediated rejection response. In Press (accepted May 31, 2020). Journal of the American Society of Nephrology.
  • Ray KN, Ettinger A, Dwarakanath N, Mistry SV, Bey J, Chaves-Gnecco D, Alston K, Ripper L, Lavage DR, Landsittel DP, Miller E. Rapid-cycle community assessment of health-related social needs of children and their families during COVID-19. In Press. (accepted October 10, 2020). Academic Pediatrics.

2019 Publications:

  • Hughes A, Zhao D, Dai H, Abou-Daya K, Tieu R, Rammal R, Williams AL, Landsittel D, Shlomchik W, Morelli A, Oberbarnscheidt MH. Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts. The Journal of Clinical Investigations. 2019 Nov 25;130(1).. https://doi.org//10.1172/JCI125773. 
  • Radovic A, Li Y, Landsittel D, Stein B, Miller E. A Social Media Website (Supporting our Valued Adolescents) to Support Treatment Uptake for Adolescents with Depression and/or Anxiety and Their Parents: Protocol for a Pilot Randomized Controlled Trial. Journal of Medical Internet Research Protocols. 2019 Jan 23;8(1):e12117. PubMed PMID: 30672741. PMCID: PMC6364211.
  • Schnetz MP, Hochheiser HS, Danks D, Landsittel DP, Vogt KM, Ibinson JW, Whitehurst SL, McDermott S, Duque MG, Kaynar AM. The triple variable index, a novel methodology identifies shared patterns of integrated physiology expressed across a diverse surgical population. BMC Medical Research Methodology. 2019 Jan 14;19(1):17. PubMed PMID: 30642260. PMCID: PMC6332613.
  • Macedo C, Hadi K, Walters J, Elinoff B, Marrai M, Zeevi A, Ramaswami B, Chalasani G, Landsittel D, Shields A, Alloway R, Woodle ES, Lakkis F, Metes D. Impact of Induction Therapy on Circulating T Helper Cells and Subsequent Donor-Specific Antibody Formation After Kidney Transplant. Kidney International Reports. 2019, 4:455–469.
  • Yu ASL, Shen C, Landsittel DP, Grantham JJ, Cook LT, Torres VE, Chapman AB, Bae KT, Mrug M, Harris PC, Rahbari-Oskoui FF, Flessner MF, Bennett WM. Long-term trajectory of kidney function in autosomal dominant polycystic kidney disease. Kidney Int. 2019 95(5), pp.1253-1261. PubMed PMID: 30922668.
  • Landsittel D, Chang C-C H, Morton, SC. (2019). Guidance for Researchers on Optimal Methods for Conducting Comparative Effectiveness Research With Observational Data. Washington, DC: Patient-Centered Outcomes Research Institute (PCORI). https://doi.org/10.25302/11.2019.ME.130603827
  • Bae, K.T., Zhou, W., Shen, C., Landsittel, D.P., Wu, Z., Tao, C., Chapman, A.B., Torres, V.E., Alan, S.L., Mrug, M. and Bennett, W.M., 2019. Growth Pattern of Kidney Cyst Number and Volume in Autosomal Dominant Polycystic Kidney Disease. Clinical Journal of the American Society of Nephrology, 14(6), pp.823-833.
  • Hayek SS, Landsittel D, Wei C, Zeier M, Yu A, Torres V, Roth S, Pao CS, and Reiser J. 2019. Soluble Urokinase Plasminogen Activator and Decline in Kidney Function in Autosomal Dominant Polycystic Kidney Disease. Journal of the American Society of Nephrology, 30: 1305–1313.

2018 Publications:

  • Yu ASL, Chir B, Shen C, Landsittel DP, Torres VE, Mrug M, Bae KT, Grantham JJ, Harris PC, Rahbari-Oskoui FF, Flessner MF, Bennett WM, Chapman A. Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease. Kidney Int. 2018 93(3):691-699. PubMed PMID: 29290310. PMCID: PMC5826779.
  • Petrov AA, Traister RS, Crspo MM, Silveira FP, Ensor CR, Landsittel D, Pilewski JM. A prospective observational study of hyogammaglobulinemia in the first year after lung transplant. Transplant Direct. 2018 Jul 12;4(8):e372. PubMed PMID: 30255132. PMCID: PMC6092181.
  • Shaikh N, Hoberman A, Hum SW, Muniz G, Kurs-Lasky M, Landsittel D, Shope T. Development and validation of a calculator for estimating the probability of urinary tract infections in young febrile children. JAMA Pediatr. 2018 Jun 1;172(6):550-556. PubMed PMID: 29710324. PMCID: PMC6137527 [Available on 2019-04-16].
  • Puttarajappa CM, Hariharan S, Humar A, Paliwal Y, Gao X, Cruz RJ, Ganoza AJ, Landsittel D, Bhattarai M, Sogawa H. Outcomes of Adult Intestinal Transplant Recipients Requiring Dialysis and Renal Transplantation. Transplant Direct. 2018 Jul 20;4(8):e377. PubMed PMID: 30255137. PMCID: PMC6092176.
  • Amin W, Linkov F, Landsittel D, Siverstein J, Becich M. Factors Influencing Malignant Mesothelioma Survival in the National Mesothelioma Virtual Bank Cohort. F1000 Research. 2018, 7:1184. PubMed PMID: 30410729. PMCID: PMC6198263.
  • McKenzie KA, Mirelle El Ters BS, Torres VE, Harris PC, Chapman AB, Mrug M, Rahbari-Oskoui5 FF, Bae KT, Landsittel DP, Bennett WM, Yu ASL, Mahnken JD. Relationship between caffeine intake and autosomal dominant polycystic kidney disease progression. BMC Nephrology. 2018 Dec 27;19(1):378. PubMed PMID: 30591038. PMCID: PMC6307167.

2017 Publications

  • Liapis H, Gaut JP, Klein C, Bagnasco S, Kraus E, Farris AB 3rd, Honsova E, Perkowska-Ptasinska A, David D, Goldberg J, Smith M, Mengel M, Haas M, Seshan S, Pegas KL, Horwedel T, Paliwa Y,  Gao X,  Landsittel D, Randhawa P: Banff Working Group. Banff histopathological consensus criteria for preimplantation kidney biopsies. Am J Transplant. 2017 Jan;17(1):140-150. PubMed PMID: 27333454. PMCID: PMC6139430.
  • Cherukuri A, Salama AD, Carter CR, Landsittel D, Arumugakani G, Clark B, Rothstein DM, Baker RJ. Reduced Human Transitional B cell T1/T2 Ratio Is Associated with Subsequent Deterioration in Renal Allograft Function. Kidney Int. 2017 Jan;91(1):183-195. PubMed PMID 28029430.
  • Thurston RC, Chang Y, Barinas-Mitchell E, von Känel R, Jennings JR, Santoro N, Landsittel DP, Matthews KA. Child abuse and neglect and subclinical cardiovascular disease among midlife women. Psychosom Med. 2017 May;79(4), 441-449. PubMed PMID: 27763988. PMCID: PMC5477855.
  • Shen C, Landsittel D, Irazabal MV, Yu AS, Chapman AB, Mrug M, Grantham JJ, Bae KT, Bennett WM, Flessner MF, Torres VE. Performance of the CKD-EPI equation to estimate GFR in a longitudinal study of Autosomal Dominant Polycystic Kidney Disease. Am J Kidney Dis. 2017 Mar;69(3):482-484. PubMed PMID: 28027795. PMCID: PMC5497695.
  • Rosenberger EM, DeVito Dabbs AJ, DiMartini AF, Landsittel DP, Pilewski JM, Dew MA. Long-Term Follow-up of a Randomized Controlled Trial Evaluating a Mobile Health Intervention for Self-Management in Lung Transplant Recipients. Am J Transplant. 2017 May; 17(5):1286.1293. PubMed PMID: 27664940. PMCID: PMC5365382.
  • Hughes AM, Patterson PD, Weaver MD, Gregory ME, Sonesh SC, Landsittel DP, Krackhardt D, Hostler D, Lazzara EH, Wang X, Vena JE, Salas E, Yealy DM. Teammate familiarity, teamwork, and risk of workplace injury in Emergency Medical Service teams. J Emerg Nurs. 2017 Jul;43(4): 339-346. PubMed PMID: 28366241.
  • Taira D, Seto B, Davis J, Seto T, Landsittel D, Sumida W. Examining factors associated with non-adherence and identifying providers caring for nonadherent subgroups. J Pharm Health Serv Res. 2017 Dec;8(40:247-253. PubMed PMID: 29151900. PMCID: PMC5690547.
  • Kline TL, Korfiatis P, Edwards ME, Bae KT, Yu A, Chapman AB, Mrug M, Grantham JJ, Landsittel D, Bennett WM, King BF, Harris PC, Torres VE, Erickson B; CRISP Investigators. Image Texture Features Predict Renal Function Decline in Patients with Autosomal Dominant Polycystic Kidney Disease. Kidney Int. 2017 92(5):1206-1216. PubMed PMID: 28532709. PMCID: PMC5651185.
  • Sentell TL, Shen C, Landsittel D, Mays MH, Southerland J, King MH, Taira DA. Racial/ethnic differences in those accompanying Medicare patients to the doctor: Insights from the 2013 Medicare Current Beneficiary's Survey. J Immigr Minor Health. 2018 Aug 20;20(4):776-783. PubMed PMID: 28405871. PMCID: PMC5656534 [Available on 2019-08-01].
  • Thurston RC, Chang Y, Barinas-Mitchell E, Jennings JR, von Känel R, Landsittel DP, Matthews KA. Physiologically assessed hot flashes and endothelial function among midlife women. Menopause. 2017 24(8):886-893. PubMed PMID: 28399007. PMCID: PMC5524590.
  • Gao B, Long C, Zhang Z, Gao X, Landsittel D, Ezzelarab M, Arares D, Liu Q, Cooper DKC, Wang Y, Hara H. Anti-Neu5Gc and Anti-Non-Neu5Gc antibodies in healthy humans. PLoS One. 2017 Jul 17;12(7). [eCollection] 2017. PubMed PMID: 28715486. PMCID: PMC5513429.
  • Taira DA, Shen C, King M, Landsittel D, Mays MH, Sentell T, Southerland J. Access to Medications for Medicare Enrollees Related to Race/Ethnicity: Results from the 2013 Medicare Current Beneficiary Survey. Res Social Adm Pharm. 2017 Nov;13(6):1208-1213. PubMed PMID: 27914950. PMCID: PMC5500432.
  • Landsittel D, Kessler L, Schmid C, Marantz P, Suarez-Almazor M. Training in Patient-Centered Outcomes Research for Specific Researcher Communities. J Clin Transl Sci. 2017 Oct;1(5):278-284. PubMed PMID: 29707248. PMCID: PMC5915813.
  • Sevco TJ, Landsittel DP, Shen C, & Moreland LW. Increased prevalence of ANA and Anti-SSA in African American rheumatoid arthritis patients is not associated with increased serum chemokine concentrations. Int. J. Clin. Rheumatol. 2017 12(5), 129-136.

2016 Publications

  • Chidi AP, Bryce CL, Myaskovsky L, Fine MJ, Geller DA, Landsittel DP, Tsung A. Differences in Physician Referral Drive Disparities in Surgical Intervention for Hepatocellular Carcinoma: A Retrospective Cohort Study. Ann Surg. 2016 Feb;263(2):362-368. PubMed PMID: 25563883. PMCID: PMC4492904.
  • Davison JM, Landau M, Luketich JD, Foxwell TJ, Landsittel DP, Gibson MK, Nason KS. A Model Based on Pathologic Features of Superficial Esophageal Adenocarcinoma Complements Clinical Node Staging in Determining Risk of Metastasis to Lymph Nodes. Clin Gastroenterol Hepatol. 2016 Mar;14(3):369-377. PubMed PMID: 26614096. PMCID: PMC4776749.
  • Mathews LR, Lott JM, Isse K, Lesniak A, Landsittel D, Demetris AJ, Sun Y, Mercer DF, Webber SA, Zeevi A, Fisher RT, Feingold B, and Turnquist HR. Elevated ST2 Distinguishes Incidences of Pediatric Heart and Small Bowel Transplant Rejection. Am J Transplant. 2016 Mar. 16(3):938-950. PubMed PMID: 26663613. PMCID: PMC5078748.
  • Thurston RC, Matthews KA, Chang Y, Santoro N, Barinas-Mitchell E, Jennings JR, von Känel R, Landsittel D, Chang YF. Changes in heart rate variability during vasomotor symptoms among midlife women. Menopause. 2016 May;23(5):499-505. PubMed PMID: 26926327. PMCID: PMC4844776.
  • Tohme S, Varley PR, Landsittel DP, Chidi AP, Tsung A. Preoperative anemia and postoperative outcomes after hepatectomy. HPB (Hepato-Pancreato-Biliary). 2016 Mar;18(3):255-61.PubMed PMID: 27017165. PMCID: PMC4814609.
  • Tanaka T, Fujita M, Bottino R, Piganelli JD, McGrath K, Li J, Lee W, Iwase H, Wijkstrom M, Bertera S, Long C, Landsittel D, Haruma K, Cooper DK, Hara H. Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigs. Islets. 2016;8(1):1-12. PubMed PMID: 26857703. PMCID: PMC4878262.
  • Kim Y, Ge Y, Tao C, Zhu J, Chapman AB, Torres VE, Yu AS, Mrug M, Bennett WM, Flessner MF, Landsittel DP, Bae KT; Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP). Automated segmentation of kidneys from MR images in subjects with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 2016 Apr 7;11(4):576-584. PubMed PMID: 26797708. PMCID: PMC4822671.
  • Patterson PD, Weaver MD, Landsittel DP, Krackhardt D, Hostler D, Vena JE, Hughes AM, Salas E, Yealy DM. Teammate familiarity and risk of injury in emergency medical services. Emerg Med J. 2016 Apr;33(4):280-285. PubMed PMID: 26614096. PMCID: PMC5441843.
  • Sood P, Gao X, Mehta R, Landsittel D, Wu C, Nusrat R, Tevar AD, Humar A, Hariharan S. Kidney transplant outcomes after primary, repeat and kidney after nonrenal solid organ transplantation: A single-center experience. Transplant Direct. 2016 May 4;2(5):e75. PubMed PMID: 27500265. PMCID: PMC4946525.
  • Dunn MA, Josbeno DA, Schmotzer AR, Tevar AD, DiMartini AF, Landsittel DP, Delitto A. The gap between clinically assessed physical performance and objective physical activity in liver transplant candidates. Liver Transpl. 2016 Oct;22(10):1324-1332. PubMed PMID: 27348200.
  • Heyer CM, Sundsbak JL, Abebe KZ, Chapman AB, Torres VE, Grantham JJ, Bae KT, Schrier RW, Perrone RD, Braun WE, Steinman TI, Mrug M, Yu AS, Brosnahan G, Hopp K, Irazabal MV, Bennett WM, Flessner MF, Moore CG, Landsittel D, Harris PC; HALT PKD and CRISP Investigators. Predicted Mutation Strength of Nontruncating PKD1 Mutations Aids Genotype-Phenotype Correlations in Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2016 Sep; 27(9):2872-2884. PubMed PMID: 26823553. PMCID: PMC5004648.
  • Chidi AP, Bryce CL, Donohue JM, Fine MJ, Landsittel DP, Myaskovsky L, Rogal SS, Switzer GE, Tsung A, Smith KJ. Economic and public health impacts of policies restricting access to Hepatitis C treatment for Medicaid patients. Value Health. 2016 Jun;19(4):326-334. PubMed PMID: 27325324. PMCID: PMC4916393.
  • Dunn MA, Josbeno DA, Tevar AD, Rachakonda V, Ganesh SR, Schmotzer AR, Kallenborn EA, Behari J, Landsittel DP, DiMartini AF, Delitto A. Frailty as tested by gait speed is an independent risk factor for cirrhosis complications that require hospitalization. Am J Gastroenterol. 2016 Dec;111(12):1768-1775. PubMed PMID: 27575708.
  • Kim Y, Bae SK, Cheng T, Tao C, Ge Y, Chapman AB, Torres VE, Yu AS, Mrug M, Bennett WM, Flessner MF, Landsittel DP, Bae KT. Automated segmentation of liver and liver cysts from bounded abdominal MR images in patients with autosomal dominant  polycystic kidney disease. Phys Med Biol. 2016 Nov 21;61(22):7864-7880. PubMed PMID: 27779124. PMCID: PMC5244890.
  • Thurston RC, Chang Y,Barinas-Mitchell E, Jennings JR, Landsittel DP, Santoro N, von Känel R, Matthews KA. Menopausal Hot Flashes and Carotid Intima Media Thickness Among Midlife Women. Stroke. 2016 Dec;47(12), 2910-2915. PubMed PMID: 27834746. PMCID: PMC5134903.

Other Selected Publications:

  • Costlow M, Landsittel DP, James AE, Kahn JM, Morton S. Model for a Patient-Centered Comparative Effectiveness Research Center. Clin Transl Sci. 2015 Apr; 8(2):155-159. PubMed PMID: 25588873. PMCID: PMC4405440.
  • Schneider M, Glick R, Stevans J, Landsittel D, Haas M. Comparison of Spinal Manipulation Methods and Usual Medical Care for Acute Low Back Pain: A Randomized Clinical Trial. Spine. 2015 Feb 15; 40(4):209-217. PubMed PMID: 25423308. PMCID: PMC4326596.
  • Landsittel D, Zhuang Z, Newcomb W, and BerryAnn R. Determining Sample Size and a Passing Criterion for Respirator Fit Test Panels. J Occup Environ Hyg. 2014;11(2): 77-84. PubMed PMID: 24369929.
  • Vallyathan V, Landsittel DP, Petsonk EL, Kahn J, Parker JE, Osiowy KT, Green FH. The Influence of dust standards on the prevalence and severity of coal worker's pneumoconiosis at autopsy in the United States of America. Arch Pathol Lab Med. 2011 Dec;135:1550-6. PubMed PMID: 22129182.
  • Landsittel D. Estimating model complexity of feed-forward neural networks. Journal of Modern and Applied Statistical Methods. 2011;8(2):488-504. PubMed PMID not provided (not federally funded).
  • Landsittel D, Donohue-Babiak N. Effect of adding fold-change criteria to significance testing of microarray data. Journal of Simulation and Statistical Computation. 2010;80(1):89-97. PubMed PMID not provided (not federally funded).
  • Barr DB, Landsittel D, Nishioka M, Thomas K, Curwin B, Raymer J, Donnelly KC, McCauley L, Ryan PB. A survey of laboratory and statistical issues related to farmworker exposure studies. Environ Health Perspect. 2006 Jun;114(6):961-8. PubMed PMID: 16760001. PMCID: PMC1480509.
  • Landsittel D, Singh H, Arena VC, Anderson SJ. Null distribution of the likelihood ratio statistic for feed-forward neural networks. Journal of Modern and Applied Statistical Methods. 2002;1(2):333-42. PubMed PMID not provided (not federally funded).
  • Landsittel DP, Murphy DJ, Kiernan NE, Hard DL, Kassab C. Evaluation of the effectiveness of educational interventions in the Pennsylvania Central Region Farm Safety Pilot Project. Am J Ind Med. 2001 Aug;40(2):145-52. PubMed PMID: 11494342.
  • Wassell JT, Gardner LI, Landsittel DP, Johnston JJ, Johnston JM. A prospective study of back belts for prevention of back pain and injury. JAMA. 2000 Dec 6;284(21):2727-32. PubMed PMID: 11105177.
  • Gardner LI, Landsittel DP, Nelson NA, Pan CS. Misclassification of physical work exposures as a design issue for musculoskeletal intervention studies. Scand J Work Environ Health. 2000 Oct;26(5):406-13. PubMed PMID: 11103839.
  • Hendricks SA, Landsittel DP, Amandus HE, Malcan J, Bell J. A matched case-control study of convenience store robbery risk factors. J Occup Environ Med. 1999 Nov;41(11):995-1004. PubMed PMID: 10570506.
  • Gardner LI, Landsittel DP, Nelson NA. Risk factors for back injury in 31,076 retail merchandise store workers. Am J Epidemiol. 1999 Oct 15;150(8):825-33. PubMed PMID: 10522653.
  • Landsittel D, Hard D, Murphy D, Kiernan NE. The Pennsylvania Central Region Farm Safety Pilot Project: Part II—Baseline data associations between approach-to-safety and hazard conditions. Journal of Agricultural Safety and Health. 1998;Special Issue (1):21-8. PubMed PMID not provided (not federally funded).
  • Landsittel D, Gardner LI, Arena VC. Identifying populations at high risk for occupational back injury with neural networks. Human and Ecological Risk Assessment. 1998;4(6):1337-52. PubMed PMID not provided (not federally funded).

 

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